MCH-404 Bioorganic Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-404: Bioorganic Chemistry Syllabus 

Unit-I Introduction 

Basic Consideration, Proximity effects and molecular adoption.

Enzymes: Introduction, Chemical and Biological catalysis, remarkable properties of enzymes,

Nomenclature and classification, concept and identification of active site by use of inhibitors,

reversible & irreversible inhibition.

Unit-II Kinds of Reactions Catalyzed by Enzymes: 

B-cleavage and consideration, some isomerization

and rearrangement reactions. Enzyme catalyzed carboxylation and decarboxylation.

Mechanism of Enzyme action: Transition state theory, Orientation and steric effect, acid-base

catalysis, covalent catalysis.

Co-Enzyme Chemistry: 

Cofactors as derived from vitamins, coenzymes, prosthetic groups,

apoenzymes, Structure and biological functions of coenzyme A.

Unit-III Enzyme Models :

 Host guest chemistry, Chiral recognition and catalysis, molecular recognition,

molecular asymmetry and prochirality, Biomimetic chemistry, crown ethers, cryptates,

cyclodextrins, cyclodextrin based enzyme models, Calixarenes, ionophores, micelles synthetic

enzyme or synzymes.

Unit-IV Biotechnological Application of enzymes: 

Large scale production and purification of enzymes,

techniques and methods of immobilization of enzyme activity, application of immobilized

enzymes, effect of immobilization on Enzyme activity, application of immobilized enzymes.

Clinical uses of enzymes, enzyme therapy, enzymes and recombinant DNA technology.

Books Suggested

1. Bioorganic chemistry:A Chemical Approch to Enzyme action,Hermann Dugas and

C.Penny, Springer-Verag.

2. Understanding Enzymes, Trevor Palmer, Prentice Hall

3. Enzyme Chemistry: Impact and applications, Ed Collin J Suckling, Chapman and Hall

4. Enzyme mechanism a Ed. M.I.Page and A. Williams, Royal society of chemistry

5. Fundamentals of Enzymology, N.C. Price and L. Stevens, Oxford University Press.

6. Enzymattic Reaction Mechanism C. Walsh,W.H. Freeman.

7. Enzyme Structure and Mechanism A Fersht, W.H.Freeman.

8. Biochemistry : The Chemical reaction of leaving cells, D.E.Metzler, Academic Press.

9. Biochemistry(4th edn.) Stryer, L.W.; H.Freeman & Co.(1995)

10. Understanding Enzymes Palmer, T.; Prantice Hall (1995).

MCH-205: Organometallic Chemistry Syllabus M.Sc.(CHEMISTRY) 2nd-II Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Second-2nd- II Semester Curriculum/ Syllabus

MCH-205: Organometallic Chemistry Syllabus

Unit I : Main Group Organometallics

Synthesis and reactions of organolithium compounds; Synthesis and reactions of organomagnesium compounds; Organometallics of zinc and mercury: preparation, structure, bonding and reactions of aluminum organyls; Thallium(I) organyls (synthesis of TlCp); Organyls of sodium, synthesis of NaCp; Silicon and tin organyls of coordination number 4. 

 Unit II : Transition Metal–Carbon Bond

Transition Metal–Carbon σ-Bond: Brief review of metal alkyl compounds; transition metalcarbene and transition metal-carbyne compounds; transition metal vinylidene and transition metal allenylidene compounds. Cyclopropenyl cation (C3R3 +) as a ligand; C4R4 as a ligand (R = H, Me, Ph)

Unit III : Syntheses of Cyclopentadienyl and Arene Metal Analogues

Synthesis and reactions of cyclopentadienyl metal carbonyls, cyclopentadienyl metal hydrides, cyclopentadienyl metal halides, arene metal carbonyls, η6-arene-chromium tricarbonyl in organic synthesis.

Unit IV : Applications to Organic Synthesis and Homogeneous Catalysis

(a) In Organic Synthesis: Hydrozirconation of alkenes and alkynes; Carbonylation of Colman’s  reagent; η4-diene iron-tricarbonyls in organic synthesis

(b) In Catalysis: Asymmetric hydrogenation; synthesis of acetic acid and glycol (Monsanto acetic acid process); Arylation/vinylation of olefins (Heck reaction); Wacker process (olefin oxidation); Asymmetric epoxidation.

Text Books

1. C. Elschenbroich. Organometallics (3rd edn.), Wiley-VCH Publication (2006).

2. C. Elschenbroich & A. Salzer. Organometallics – A Concise Introduction (2nd edn.),VCH Publication (1992).

3. F. Mathey & A. Sevin. Molecular Chemistry of the Transition Elements, John Wiley (1996).

4. F. A. Cotton & G. Wilkinson. Advanced Inorganic Chemistry (5th edn.), John Wiley (1988).

5. R. C. Mehrotra & A. Singh. Organometallic Chemistry: A Unified Approach (2nd edn.), New

Age International (2000).

MCH-205-Organometallic-Chemistry-Syllabus-Msc-CHEMISTRY-2nd-II-Sem-Syllabus-for-DAVV-Indore-Affiliated-Institutions 

MCH-305 Organic Synthesis Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-305: Organic Synthesis Syllabus

Unit -I The disconnection approach (Retrosynthetic analysis):

Guidelines to choose disconnection, Synthons and synthetic equivalents, Functional group interconversion, the order of events and its guidelines, One-group C-X disconnections, Two-group C-X disconnections, Chemoselectivity, reversal of polarity, cyclization reactions and summary of strategy.Amine synthesis, Stereoselectivity, stereoselective reactions, stereospecific reactions

Unit - II : One group C-C disconnections

 Alcohols, carbonyl compounds, regioselectivity. Use of acetylenes Two-group C-C disconnections:Diels-Alder reactions (stereospecificity, stereoselectivity, endo-selectivity, regioselectivity), 1,3-Difunctionalised and ,- unsaturated carbonyl compounds, 1,5- Difunctionalised compounds, Michael addition and Robinson Annelation.

Unit – III : Oxidation Processes

Introduction, Different oxidative processes. Mn(VII) oxidants:Oxidation of alcohols,alkenes,alkynes,aldehydes,ketones,aromatic side chains and rings,amines Cr (VI) oxidants:Oxidation of alcohols /phenols(Jones reagent,Collins reagent,PCC,PDC), alkanes,alkenes,aromatic side chain and aromatic nucleus. Oxidation with peracids: oxidation of alkenes ,ketones.

Other oxidants: Oxidation with ruthenium tetraoxide, lead tetra acetate, thallium. (III) nitrate,potassium periodate,aluminium tri-isopropoxide and aluminium tri-t-butoxide, hydrogen

peroxide, t-Butyl hydroperoxide 

Unit- IV : Reduction Processes

Introduction, Different reductive processes. Catalytic hydrogenation: Heterogeneous hydrogenation, Homogeneous hydrogenation. Metal hydride reduction :Scope, Mechanism, stereochemical aspects of metal hydride reduction using lithium aluminium hydride,Sodium borohydride, Diboranes eduction by dissolving metals: Scope and basic mechanism, Clemensen reduction, Birch reduction Reduction by other reducing agents: Hydrazines, Diimide

Books suggested

1. S. Warren ,Designing Organic Synthesis, Wiley.

2. J. Fuhrhop and G. Penzillin, Organic synthesis – Concept, Methods and Starting Material, Verlage VCH.

3. W. Carruthers,Some Modren Methods of Organic Synthesis, Cambrige Univ. Press.

4. H.O. House, Modern Synthetic Reactions, W.A. Benjamin

5. V.K.Ahluwalia ,Organic Reaction Mechanisms, Narosa Publishing House

6. S.M.Mukherji and S.P.Singh,Reaction Mechanism in Organic Chemistry, Macmilan

7. J. March, Advanced Organic Synthesis: Reaction, Mechanisms and Structure, Wiley.