MCH-404 Bioorganic Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-404: Bioorganic Chemistry Syllabus 

Unit-I Introduction 

Basic Consideration, Proximity effects and molecular adoption.

Enzymes: Introduction, Chemical and Biological catalysis, remarkable properties of enzymes,

Nomenclature and classification, concept and identification of active site by use of inhibitors,

reversible & irreversible inhibition.

Unit-II Kinds of Reactions Catalyzed by Enzymes: 

B-cleavage and consideration, some isomerization

and rearrangement reactions. Enzyme catalyzed carboxylation and decarboxylation.

Mechanism of Enzyme action: Transition state theory, Orientation and steric effect, acid-base

catalysis, covalent catalysis.

Co-Enzyme Chemistry: 

Cofactors as derived from vitamins, coenzymes, prosthetic groups,

apoenzymes, Structure and biological functions of coenzyme A.

Unit-III Enzyme Models :

 Host guest chemistry, Chiral recognition and catalysis, molecular recognition,

molecular asymmetry and prochirality, Biomimetic chemistry, crown ethers, cryptates,

cyclodextrins, cyclodextrin based enzyme models, Calixarenes, ionophores, micelles synthetic

enzyme or synzymes.

Unit-IV Biotechnological Application of enzymes: 

Large scale production and purification of enzymes,

techniques and methods of immobilization of enzyme activity, application of immobilized

enzymes, effect of immobilization on Enzyme activity, application of immobilized enzymes.

Clinical uses of enzymes, enzyme therapy, enzymes and recombinant DNA technology.

Books Suggested

1. Bioorganic chemistry:A Chemical Approch to Enzyme action,Hermann Dugas and

C.Penny, Springer-Verag.

2. Understanding Enzymes, Trevor Palmer, Prentice Hall

3. Enzyme Chemistry: Impact and applications, Ed Collin J Suckling, Chapman and Hall

4. Enzyme mechanism a Ed. M.I.Page and A. Williams, Royal society of chemistry

5. Fundamentals of Enzymology, N.C. Price and L. Stevens, Oxford University Press.

6. Enzymattic Reaction Mechanism C. Walsh,W.H. Freeman.

7. Enzyme Structure and Mechanism A Fersht, W.H.Freeman.

8. Biochemistry : The Chemical reaction of leaving cells, D.E.Metzler, Academic Press.

9. Biochemistry(4th edn.) Stryer, L.W.; H.Freeman & Co.(1995)

10. Understanding Enzymes Palmer, T.; Prantice Hall (1995).