MCH-406 Chemistry of Natural Products Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-406: Chemistry of Natural Products Syllabus

Unit – I : Terpenoids

Structure determination, stereochemistry, biosynthesis and synthesis of some common terpenopids Citral, α-Terpeneol, Farnesol, Zingiberence, Santonin, Phytol and Abietic acid.

Unit –II : Alkaloids

Structure, stereochemistry, synthesis and biosynthesis of some common alkaloids Ephedrine, Nicotine, Atropine, (+) Conin ,Quinine and Morphine.

Unit –III : 

[a] Steroids: 

Occurrence, nomenclature, basic skeleton, Diel's hydrocarbon and stereochemistry, Isolation, Structure determination and synthesis of: Cholesterol, Bile acids. Harmons: Androsterone, Testosterone, Ostrone, Progesterone, Aldosterone, Biosynthesis of Steroids.

[B] Prostaglandis

Occurrence, nomenclature, classification, biogenesis and physiological effects.

Synthesis of PGE2 and PGF2a.

Unit -IV 

[A] Plant Pigments

Occurrence, nomenclature and general methods of structure determination. Isolation and synthesis of Apigenin, Luteolin Quercetin, Myrcetin, Vitexin, Diadzein, Aureusin, Cyanidin, Hirsutidin, Biosynthesis of flavonoids: Acetate pathway and Shikimic acid pathway. Prophyrins:

Structure and synthesis of Haemoglobin and Chlorophyll.

[B] Pyrethroids and Rotenones

Synthesis and reactions of Pyrethroids and Rotenones. (For structure elucidation, emphasis is to be placed on the use of spectral parameters wherever possible).

Suggested Books:

1. Organic Chemistry : Vol. 1 and 2, I. L. Finar, ELBS

2. Organic Chemistry of Natural Products Vol. I and Vol. II, Gurdeep R. Chatwal, Himalaya Publishing House

3. Stereoselective Synthesis: A Practical Approach, M. Norgradi, VCH.

4. Rodd's Chemistry of Carbon Compounds, Ed. S. Coffey, Elsevier.

5.Introduction to Flavonoids, B.A. Bohm. Harwood Academic Publishers.

6. New Trends in Natural Product chemistry, Ataaur Rahman and M.L. Choudhary,

Harwood Academic Publishers.

7. Insecticides of Natural Origin, Sukh Dev, Harwood Academic Publishers.

MCH-403 Analytical Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-403: Analytical Chemistry Syllabus

Unit -I Statistical tests and Error Analysis:

Accuracy, precision, classification of errors, significant figures and computation, mean deviation and standard deviation, Least square methods, regression coefficient , F-test, t-test and Chi-test. 

 Sampling and Sample Treatment: Factors involved in effective sampling, good samples; Representative and homogeneous,

samples of mixtures.

Unit –II Spectrochemical and Thermal Methods :

Spectrophotometry: Quantities principles of absorption, instrumentation, single beam, double

beam, determination of pKa value of an indicator, detectors, applications.

Atomic spectroscopy: Principles of emissions, atomic emission spectroscopy and flame emission

spectroscopy, monochromator, detector, types of interferences,

Thermal methods of analysis: Principles and instrumentation of TG and DTA. Complementary

nature of TG and DTA. Differential scanning calorimeter (DSC). Applications of thermal

methods in analytical chemistry .

Unit –III Electroanalytical Methods:

Theory of electrogravimetric analysis, electrode reactions, over potential, Cyclic voltammetry,

Linear-scan voltammetry, Pulse voltammetric methods, stripping methods.

Coulometry : Coulometrc titrations and controlled- potential electrolysis.

Unit - IV Separation Techniques :

Classification of chromatographic separations. Theory of chromatography. Applications of

chromatographic methods: Adsorption and partition chromatography. Ion exchange

chromatography , LC, HPLC and GC, Column matrices, Detectors. Affinity and chiral

columns.

Principles of analytical separations, liquid –liqid extraction : Distribution coefficient,

distribution ratio, solvent extraction of metals, analytical separations, multiple batch extractions,

countercurrent distribution., multiple extractions.

Books Suggested

1. Gary D.Christian, Analytical Chemistry, John-Wiley

2. H.A.Willard, L.L.Merrit, and J.A.Dean, Instrumental Methods of Analysis, Van

Nostrand, New York, 1986.

3. D.A.Skoog & D.M.West Principles of Instrumental Analysis. Holt Rinahart Winston,

New York, 1988.

4. K A Robinsons Chemical Analysis, Harper Collins Publishers, NewYork.

5. A.J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications,

John Wiley & Sons: New York.

MCH-306 Advanced Medicinal Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-306: Advanced Medicinal Chemistry Syllabus

Unit –I : Antineoplastic agents

Introduction, cancer chemotherapy, role of alkylating agents and antimetabolite in treatment of cancer, carcinolytic antibiotics, and mitotic inhibitors, Synthesis of mechlorethamine,  cyclophosphamide, melphalan, uracil, mustards and 6-mercaptopurine, recent development in

cancer chemotherapy.

Unit –II : Psychoactive drugs-The chemotherapy of mind

Introduction, neurotransmitters, CNS depressants, general anesthetics, mode of action of hypnotics, sedatives, anti-anxiety drugs, benzodiazipines, buspirone, neurochemistry of mental

diseases, Anti psychotic drugs the neuroleptics, anti-depressants, butyro phenones, serendipity and drug development, stereo chemical aspects of psychotropic drugs. Synthesis of diazepam, oxazepam, chlorazepam, alprazolam, phenytoin, ethosuximide, trimethadione, barbiturates, thiopental sodium, gluthemide.

Unit –III : Tranquilizers:-

Phenothiazine derivatives - structure- activity relationship, metabolism and mode of action; other tranquilizers. Synthesis of chlorpromazine.

Sulpha Drugs:

Classification, structure-activity-relationship, Mode of action. Synthesis: Sulphadiazine, Sulphaisoxazole, Sulphadimethoxine.

Unit –IV: Diuretics (Drugs acting on renal system):

 Classification, structure-activity relationships and mode of action of organomercurials, phenoxy acetic acids, purines carbonic anhydrase inhibitors, benzothiadiazines , ulphamoyl benzoic acid derivatives, endocrine antagonists.

Books recommended

1. Robert F.dorge Wilson and Gisvod. Textbook of organic Medicinal and Pharmaceutical Chemistry.

2. Ed. M.E. Wolff, John wiley. Berger’s Medicinal Chemistry and drug discovery, Vol-I.

3. J.Faprhop and G.Penzillin. Organic synthesis-concept, method and starting material.

4. Eds.Korolkovas and Burkhattar J.H. John Wiley & sons. Essentials of medicinal Chemistry.

5. Goodman and Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill.

6. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry, Ed Robert F. Dorge.

MCH-401 Solid State Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-401: Solid State Chemistry Syllabus

Unit I : Solid State Reactions

General principles, experimental procedure, co-precipitation as a precursory to solid state reactions, kinetics of solid state reactions.

Unit II : Crystal Defects and Non-Stoichiometry

Perfect and imperfect crystals, intrinsic and extrinsic defects-point defects, line and plane defects, vacancies-Schottky detects and Frenkel defects. Thermodynamics of Schottky and Frenkel defect formation, colour centres, non-stoichiometry and defects.

 Unit III : Electronic Properties and Band Theory

Metal,s insulators and semiconductors, electronic structure of solidsband theory band structure  of metals, insulators and semiconductors, Intrinsic and extrinsic semiconductors, doping semiconductors, p-n junctions, super conductors. Optical properties-Application of optical and electron microscopy. Magnetic Properties-Classification of materials : Effect of temperature calculation of magnetic moment, mechanism of ferro and anti ferromagnetic ordering super exchange.

Unit IV : Organic Solids

Electrically conducting solids. organic charge transfer complex, organic metals, new superconductors. 

Books Suggested

1. Solid state chemistry and its applications, A.R. West. Peenum.

2. Principles of the Solid State, H.V. Keer, Wiley Eastern.

3. Solid State Chemistry, N.B. Hannay.

4. Solid State Chemistry, D.K. Chakrabarty, New Wiley Eastern.

MCH-107 PRACTICAL Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-307: PRACTICAL Syllabus

(A) Interpretations of Electronic, Infra-red, NMR, ESR, Mössbauer, Mass and XPS spectra

(B) Electronic Spectroscopy

i. Determination of kPa of an indicator (e.g. methyl red) in (a) aqueous and (b) micellar media.

ii. Determination of stoichiometry and stability constant of Ferricisothicoyanation complex ion in solution.

iii. Electronis spectral studies for transition metal complexes.