MAP-407 PRACTICAL Syllabus M.Sc.(APPLIED CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (APPLIED CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MAP-407: PRACTICAL Syllabus

Inorganic Chemistry

Preparation
Preparation of selected inorganic compounds and their study by IR, electronic spectra, Mossbauer. ESR and magnetic susceptibility measurements. Handiling of air and moisture sensitive compounds involving vacuum lines. Selection can be made from the following :
1. Sodium amide. Inorg. Synth., 1946, 2, 128.
2. Synthesis and thermal analysis of group II metal oxalate hydrate. J. Chem. Ed., 1988, 65, 1024.
3. Atomic absorption analysis of Mg and Ca.
4. Trialkoxyboanes-IR and NMR spectra.
5. PhBd2 Dichlorophenylborane - Synthesis in vacuum line.
6. Preparation of Tin (IV) iodide, Tin (IV) chloride and Tin (II) iodide, Inorge, Synth.,
1953, 4.119.
7. Relative stability of Tin (IV) and Pb (IV). Preparation of ammonium hexachlorostannate (NH4)2 SnCl6 ammonium hexachlorophlumbate (NH4)2PbCl6.
8. Hexa-bis (4,nitrophenoxy) cyclotriphosphazene.
9. Synthesis of trichlorodiphenylantimony (V) hydrate. Inorg. Synths., 1985, 23, 194
10. Sodium tetrathionate Na2S4O6.
11. Metal complexes of dimethyl sulfoxide (IR) : CuCl2.2DMSO, PdCl2. 2DMSO, RuCl2.
4DMSO. J.Chem. Educ., 1982, 59, 57.
12. Synthesis of metal acethylacetonate : Magnetic moment, IR, NMR, Inorg. Synths, 1957, 5, 130, 1963, 1, 183.
13. Bromination of Cr (acac)3. J. Chem. Edu., 1986, 63, 90.
14. Magnetic moment of Cu (acac)2H2O.
15. Cis and Trns [Co(en)2CI2]+.
16. Separation of optical isomer of cis-[Co(en)2CI2]CI.J. Chem. Soc., 1960. 4369.
17. Ion exchange separation of oxidation state of vanadium. J. Chem. Educ., 1980, 57, 316; 1978, 55, 55

18. Determination of Cr (III) complexes. [Cr(H2O)6]NO3.3HO, [Cr(H2O)4Cl2]Cl.2H2O, [Cr(en)3]Cl3, Cr(acac)3. Inorg. synths., 1972, 13, 184.
19. Preparation of N, N bis (salicycladehyde) ethylenedimine, salen H2. Co(Salen) J. Chem. Educ., 1977, 54, 443; 1973, 50, 670.
20. Preparation of Fe(II) chloride (use it as Friedel-Craft chlorination source) J. Org. Chem.,1978, 43, 2423; J. Chem. Edu., 1984, 61, 645; 1986, 63, 361.
21. Reaction of Cr(III) with a multidentate ligand; a kinetics experiment (visible spectra Cr-EDTA complex) J.A.C.S., 1953, 75, 6570.
22. Preparation and use of Ferrocene. J. Chem. Edu. 1966, 43, 73; 1976, 53, 730.
23. Preparation of copper glycine complex-cis and trans bis (glycinato Copper (II). J. Chem. soc. Dalton, 1979, 1901, J. Chem. Edu., 1982, 59, 1052.
24. Preparation of phosphine Ph3P and its transition metal complexes.
25. Any other experimetn such as conversion of p-xylene to terephtalic acid catalyzed by CoBr2 (homogeneous catalysis).
26. Preparation of [Co(phenathroline-5,6 quinone)].

Spectrophotometric Determinations

a. Manganese/Chromium/Vanadium in steel sample.
b. Nickel/molybdenum/tungston/vanadium/uranium by extractive spectrophotometric method.
c. Fluoride/nitrite/phosphate.
d. Zirconium-alizarin Red-S complex : Mole-ratio method.
e. Copper-Ethylene diamine complex : Slope-ratio method.
f. Iron-phenanthroline complex : Job's method of continuous variations.

Flame Photometric Determinations

a. Sodium and potassium when present together.
b. Lithium/calsium/barium/strontium.
c. Cadmium and magnesium in tap water.

Chromatographic Separations

a. Cadium and zinc
b. Zinc and magnesium.
c. Thin-layer chromatography-separation of nickel, manganeses, cobalt and zinc. Determination of Rf values.
d. Separation and identification of the sugars present in the given mixture of glucose, fructorse and sucrose by paper chromatography and determination of Rf values.

Organic Chemistry

Qualitative Analysis

Separation, purification and identification of the components of a mixture of three organic compounds (three solids or two liquids and one solid or two solids and one liquid), using tc for checking the purity of the separated compounds, chemical analysis, IR, PMR and mass spectral data.

Multi-step Synthesis of Organic Compounds

The exercise should illustrate the use of organic reagents and may involve purification of the products by chromatographic techniques. Photochemical reaction Benzophenone -> Benzpinacol _> Benzpinacolone Beckmann rearrangement : Benzanilide from benzene Benzene -> Benzophenone -> Benzphenone oxime -> Benzanilide Benzilic acid rearrangement : Benzilic acid from benzoin Benzoin -> Benzil -> Benzilic acid Synthesis of heterocyclic compounds Skraup synthesis : Preparation of quinoline from aniline Fisher Indole synthesis : Preparation of 2-phenylindole from phenylhydrazine. Enzymatic synthesis Enzymatic synthesis Enzymatic reduction : reduction of ethyl acetoacetate using Baker's yeast to yield enantiomeric excess of S (+) ehtyl-3-hydroxybutanoate and determine its optical purity. Biosynthesis of ethanol from sucrose. Synthesis using microwave Alkylation of diethyl malonate with benzyl chloride. Synthesis using phase transfer catalyst. Alkylation of diethyl malonate or ethyl acetoacetate with an alkylhalide.

Extraction of Organic Compounds from Natural Sources

1. Isolation of caffeine from tea leaves.
2. Isolation of casein from milk (the students are required to try some typical colour reactions of proteins).
3. Isolation of lactose from milk (purity of sugar should be checked by LC and PC and Rf values reported).
4. Isolation of nicotine dipicrate from tobacco.
5. Isolation of cinchonine from cinchona bark.
6. Isolation of piperine from black pepper.
7. Isolation of lycopene from tomatoes.
8. Isolation of b-carotene from carrots.
9. Isolation of oleic acid from olive oil (involving the preparation of complex with urea and separation of linoleic acid).
10. Isolation of eugenol from clove.
11. Isolation of (+) limonine from citrus rind.

Paper Chromatography

Separation of identification of the sugars present in the given mixture of glucose, fructose and surcrose by paper chromatography and determination of Rf values.
Spectroscopy
Identification of organic compounds by the analysis of their spectral data (UV, IR, PMR, CMR & MS) Spectrophotometric (UV/VIS) Estimations
1. Amino acids
2. Proteins
3. Carbohydrates
4. Cholesterol
5. Ascorbic acid
6. Aspirin
7. Caffeine

Physical Chemistry

Number of hours for each experiment : 3-4 hours. a list of experiments under different headings are given below. Typical experiments are to be selected from teach type. Physical chemistry
Number of Hours to each experiment : 3 Hours. A list of experiments under different headings are given below. Typical experiments are to be selected from each type. (A) Thermodynamics
i. Determination of partial molar volume of solute (e.g. KCl) and solvent in a binary mixture.
ii. Determination of the temperature dependence of the solubility of a compound in two solvents having similar intromolecular in tetractions (benzoic acid in water and in DMSO water mixture and calculate the partial molar heat of solution.

(B) Spectroscopy

iv. Determination of kPa of an indicator (e.g. methyl red) in (a) aqueous and (b) micellar media.
v. Determination of stoichiometry and stability constant of Ferricisothicoyanation complex ion in solution.
vi. Determination of rate constant of alkaline bleaching of Malachite green and effect of ionic strength on the rate of reaction.

(C) Polarography

i. Identification and estimation of metal ions such as Cd+2, Pb+2, Zn+2, and i+2 etc. polarographically.
ii. Study of a metal ligand complex polarographically (using Lingane's Method).

(D) Chemical Kinetics

i. Determination of rate constant and formation constant of an intermediate complex in the reaction of Ce(IV) and Hypophosphorous acid at ambient temperature.
ii. Determination of energy and enthalpy of activation in the reaction of KMnO4 and benzyl alcohol in acid medium.
iii. Determination of energy of activation of and entropy of activation from a single kinetic run.
iv. Kinetics of an enzyme catalyzed reaction.

(E) Electronics

This lab course will have theory as well as practicals and the lectures shall be delivered during lab hours.

Basic Electronics

Notations used in the electronic circuit, study of electronic compounds and colour codes. Conversion of chemical quantities into electronic quantitles. transducer, illustration with electrodes, thermocouples and thermistors. Passive components : Resistors, capacitors and inductors with some emphasis on solid state properties of materials. Net works of resistors.

Thevenin's theorem, superposition theorem, loop analysis, RC circuits, LR Circuits, LCR circuits. Illustration of the use of circuits in NQR spectroscopy, Mossbauer spectroscopy cyclic voltammetry and in power supplied as filter circuits.

Active components

Introduction to ordinary diodes and Zener diode with some emphasis on p-n junction as a solid state property. Use of diode as rectifiers, clipping and clamping circuits. Power supplies. Transistors : An extension of p-n-p and n-p-n transistors. Characteristics of transistors, hybrid parameters; transistor circuits as amplifiers, high impedance (preamplifier) circuits. Darlinction
pairs, differential amplifiers.

Operational Amplifiers

Ideal characteristics; inverter, summer, integrator, differentiator, voltage follower, illustrative use of operational amplifiers. Introduction to Fourier transformation in instrumentation. List of Experiments in electronics (Do at least five experiments from this section)
1. (a) To plot the diode characteristics and find its dynamic resistance and cut in voltage.
(b) To plot the characteristics of transistor used as a diode and compare the results with those of (a)
2. To implement a diode dipper circuit for the given transffer characteristics and verify the
3. (a) To plot the diode characteristics and find its dynamic resistance and cut in voltage.
(b) To plot the characteristics of transistor used as a diode and compare the results with those
of (a)wave form.
4. To implement a diode damper circuit which damps the positive peak of the input voltage to (a) Zero voltage adn (b) a given voltage. Verify the performance.
5. (a) To plot the characgteristics of an NPN transistor in CE configuration.
(b) To find the h-paprameter of the transistor from the characteristics.
6. (a) To plot the characteristics of an NPN transistor in CB configuration.
(b) To find the h-parameter of the transistor from the characterstics and compare it with the results of experiment No. 6.
7. (a) To plot the drain and transfer chracteristics of a JEET in CS configuration.
(b) To find out the pinch off voltage, maximum drain to source saturation current and the transconductance.
8. To obtain the frequency response of an RC coupled amplifier and estimate the bandwidth.
9. (a) To plot the characteristics of Zener diode and find its dynamic resistance under reverse biased condition.
To use zener diode for a voltage regulation.
(i) Plot the line regulation curve.
(ii) Plot the load Regulation curve.
10. (a) To vire a Half wave Rectifier circuit using diode and measure the rms voltage, de voltage and to find Riple factor
(b) To study the performance of half way and full wave doubler circuits.
11. To plot the characteristics of UJT and find the peak voltage, peak current and valley voltage and use as a relaxation oscillator.

Books Suggested

1. Inorganic Experimens, J. Derek Woolings, VCH.
2. Microscale Inorganic Chemistry, Z. Szafran, R.M, Pike and M.M. Singh, Wiley.
3. Practical Inorganic Chemistry, G. Marr and B. W. Rockett, Van Nostrad.
4. The systematic Identification of Organic Compounds, R.L. Shriner and D.Y. curlin.

MAP-406 Chemical Reaction Engineering Syllabus M.Sc.(APPLIED CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (APPLIED CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MAP-406: Chemical Reaction Engineering Syllabus

Unit I : Introduction and material balances for chemical reactors.

Scope, kinetics of complex reactions, concept of stationary state , The rate expression, Material balance in chemical reactors, Batch reactors, Plug flow reactors (PFRs), Continuous stirred tank reactors (CSTRs), numerical problems.

Unit II : Calculation of reactor volume and residence time

Residence time of batch reactors, constant volume batch reactor, constant pressure batch reactor, plug flow reactors (PFRs) , continuous stirred tank reactors (CSTRs) , Comparison of PFRs and CSTRs, Reactors in series, The recycle reactor, numerical problems

Unit III :Multiple reactions

Parallel reactions, Batch reactors and PFRs, Parallel reactions of different order, Series reactions, CSTRs, Comperision of PERS and CSTRs, Problems

Unit IV: The energy balance and temperature effects

Temperature dependence of reaction rate, Reversible endothermic reactions, reversible exothermic reactions, energy balance ( CSTR, PFR and batch reactors ), Steady-state multiplicity in CSTRs, Multistage adiabatic PFR, Problems

Books:

1. Ian S Metcalfe, Chemical reaction engineering 1997
2. J M Smith, Chemical Engineering Kinetics, Third edition .

MAP-405 Industrial Catalysis Syllabus M.Sc.(APPLIED CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (APPLIED CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MAP-405: Industrial Catalysis Syllabus

Unit I : Catalysis in solutions

Introduction, Acid-base catalysis, catalysis by electron transfer, Organometallic catalysis, Catalysis by macromolecules, Phase transfer catalysis, Catalysis by micelles

Unit II : Catalysis by enzymes

Composition and structure of enzymes, Reactions catalyzed by enzymes, Nature of catalytic sites: the Uniqueness of enzymes as catalysts, Examples of enzyme structure and catalysis, Supported Enzymes,

Unit III : Catalysis by polymers:

Nature of Polymers, Attachment of Catalytic Groups to Polymer Supports, Catalysis in Polymer Gels, Adsorption and Kinetics of Polymer-Catalyzed Reactions, Interactions of Catalytic Groups: the Role of the Support, Bifunctional and Multifunctional Catalysis, Porous Polymers and Surface Catalysis, Intraparticle Transport Influence, Applications of Polymer Catalysts.

Unit IV : Catalysis by Nanomaterials 

Structures of Crystalline Solids, important preparative techniques for Nanomaterials, Catalysis by nanometerials and nano metal oxides, Structures of Zeolites (Crystalline Alluminosilicates), Families of Zeolites, Adsorption and Diffusion in Zeolites, The Solvent like Nature of Zeolite Pores, Catalysis by Zeolites, Nonzeolite Molecular Sieves, Clays and Other Layered Materials

Unit V : Catalysis on Surfaces

Nature of surfaces, Charcaterization of surfaces, important surface characterization techniques such as LEED, XPS, BET surface area measurements, XRD Kinetics of few important surface reactions like epoxidation , ammoximation and alkylation.

Book:

Catalytic Chemistry, Bruce-gates, John Wiley & Sons

MAP-404 Bioorganic Chemistry Syllabus M.Sc.(APPLIED CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (APPLIED CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MAP-404: Bioorganic Chemistry Syllabus

Unit-I: Introduction 

Basic Consideration, Proximity effects and molecular adoption.
Enzymes: Introduction, Chemical and Biological catalysis, remarkable properties of enzymes, Nomenclature and classification, concept and identification of active site by use of inhibitors, reversible & irreversible inhibition.

Unit-II : Kinds of Reactions Catalyzed by Enzymes

B-cleavage and consideration, some isomerization and rearrangement reactions. Enzyme catalyzed carboxylation and decarboxylation.
Mechanism of Enzyme action: Transition state theory, Orientation and steric effect, acid-base catalysis, covalent catalysis.
Co-Enzyme Chemistry: Cofactors as derived from vitamins, coenzymes, prosthetic groups, apoenzymes, Structure and biological functions of coenzyme A.

Unit-III : Enzyme Models :

Host guest chemistry, Chiral recognition and catalysis, molecular recognition, molecular asymmetry and prochirality, Biomimetic chemistry, crown ethers, cryptates, cyclodextrins, cyclodextrin based enzyme models, Calixarenes, ionophores, micelles synthetic enzyme or synzymes.

Unit-IV : Biotechnological Application of enzymes:

 Large scale production and purification of enzymes, techniques and methods of immobilization of enzyme activity, application of immobilized enzymes, effect of immobilization on Enzyme activity, application of immobilized enzymes. Clinical uses of enzymes, enzyme therapy, enzymes and recombinant DNA technology.

Books Suggested

1. Bioorganic chemistry:A Chemical Approch to Enzyme action,Hermann Dugas and
C.Penny, Springer-Verag.
2. Understanding Enzymes, Trevor Palmer, Prentice Hall
3. Enzyme Chemistry: Impact and applications, Ed Collin J Suckling, Chapman and Hall
4. Enzyme mechanism a Ed. M.I.Page and A. Williams, Royal society of chemistry
5. Fundamentals of Enzymology, N.C. Price and L. Stevens, Oxford University Press.
6. Enzymattic Reaction Mechanism C. Walsh,W.H. Freeman.
7. Enzyme Structure and Mechanism A Fersht, W.H.Freeman.
8. Biochemistry : The Chemical reaction of leaving cells, D.E.Metzler, Academic Press.
9. Biochemistry(4th edn.) Stryer, L.W.; H.Freeman & Co.(1995)
10. Understanding Enzymes Palmer, T.; Prantice Hall (1995).

MAP-402 Environmental Chemistry Syllabus M.Sc.(APPLIED CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (APPLIED CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MAP-402: Environmental Chemistry Syllabus

Unit I : Environment

Introduction. Composition of atmosphere, vertical temperature, temperature inversion, heat budget of the earth, atmospheric system, vertical stability atmosphere, Biochemical cycles of C, N, P, S and O. Biodistribution of elements.
Hydrosphere
Chemical composition of water bodies-lakes, streams, rivers and wet lands etc.

Hydrological cycle
Aquatic pollution – Inorganic,organic, pesticide, agriculture, industrial and sewage, detergents, oil spills and oil pollutants. Water quality parameters – dissolved oxygen, biochemical oxygen demand, solids, metals, content of chloride, sulphate, phosphate, nitrate and microorganisms. Water quality standards. Analytical methods of measuring BOD, DO, COD, F, Oils, metals (As, Cd, Cr, Hg, Pb, Se etc.),residual chloride and chlorine demand. Purification and treatment of water.

Unit II : Soils

Composition, micro and macro nutrients, pollution – fertilizers, pesticides, plastics and metals. Waste treatment.
Atmosphere : Chemical composition of atmosphere – particles, ions and radicals and their formation. Chemical and photochemical reactions in atmosphere, smog formation, oxides of N, C, S, O and their effect, pollution by chemicals, petroleum, minerals, chlorofluorohydrocarbons. Green house effect, acid rain, air pollution controls and their chemistry. Analytical methods for measuring air pollutants. Continuous monitoring instruments.

Unit III : Industrial Pollution

Cement, sugar, distillery, drug, paper and pulp, thermal power plants, nuclear power plants, metallurgy. Polymers, drugs etc.
Environmental disasters – Cherbonyl, Three mile island, Seveso and minamata disasters,Japan tsunami

Unit IV : Environmental Toxicology

Toxic heavy metals : Mercury, lead, arsenic and cadmium. Causes of toxicity. Bioaccumulation, sources of heavy metals. Chemical speciation of Hg, Pb, As, and Cd. Biochemical and damaging effects.
Toxic Organic Compound : Pesticides, classification, properties and uses of organochlorine and ionospheres pesticides detection and damaging effects.

Books Suggested

1. Environmental Chemistry, S.E. Mahan, Lewis Publishers.
2. Environmental Chemistry, Sharma & Kaur, Krishna Publishers.
3. Environmental Chemistry, A.K. De, Wiley Eastern
4. Environmental Pollution Analysis, S.M. Khopkar, Wiley Eastern
5. Standard Method of Chemical Analysis, F.J. Welcher Vol. III, Van Nostrand Reinhold Co.
6. Environmental Toxicology, Ed. S. Landsberger and M. Creatchman, Gordon and Breach Science Publication.
7. Enviromental Chemistry, C. Baird, W.H. Freeman.

MAP-401 Solid State Chemistry Syllabus M.Sc.(APPLIED CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (APPLIED CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MAP-401: Solid State Chemistry Syllabus

Unit I : Solid State Reactions

General principles, experimental procedure, co-precipitation as a precursory to solid state reactions, kinetics of solid state reactions.

Unit II : Crystal Defects and Non-Stoichiometry

Perfect and imperfect crystals, intrinsic and extrinsic defects-point defects, line and plane defects, vacancies-Schottky detects and Frenkel defects. Thermodynamics of Schottky and Frenkel defect formation, colour centres, non-stoichiometry and defects.

Unit III : Electronic Properties and Band Theory

Metal,s insulators and semiconductors, electronic structure of solidsband theory band structure of metals, insulators and semiconductors, Intrinsic and extrinsic semiconductors, doping semiconductors, p-n junctions, super conductors. Optical properties-Application of optical and electron microscopy. Magnetic Properties-Classification of materials : Effect of temperature calculation of magnetic moment, mechanism of ferro and anti ferromagnetic ordering super exchange.

Unit IV : Organic Solids

Electrically conducting solids. organic charge transfer complex, organic metals, new superconductors. 

Books Suggested

1. Solid state chemistry and its applications, A.R. West. Peenum.
2. Principles of the Solid State, H.V. Keer, Wiley Eastern.
3. Solid State Chemistry, N.B. Hannay.
4. Solid State Chemistry, D.K. Chakrabarty, New Wiley Eastern.

MCH-406 Chemistry of Natural Products Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-406: Chemistry of Natural Products Syllabus

Unit – I : Terpenoids

Structure determination, stereochemistry, biosynthesis and synthesis of some common terpenopids Citral, α-Terpeneol, Farnesol, Zingiberence, Santonin, Phytol and Abietic acid.

Unit –II : Alkaloids

Structure, stereochemistry, synthesis and biosynthesis of some common alkaloids Ephedrine, Nicotine, Atropine, (+) Conin ,Quinine and Morphine.

Unit –III : 

[a] Steroids: 

Occurrence, nomenclature, basic skeleton, Diel's hydrocarbon and stereochemistry, Isolation, Structure determination and synthesis of: Cholesterol, Bile acids. Harmons: Androsterone, Testosterone, Ostrone, Progesterone, Aldosterone, Biosynthesis of Steroids.

[B] Prostaglandis

Occurrence, nomenclature, classification, biogenesis and physiological effects.

Synthesis of PGE2 and PGF2a.

Unit -IV 

[A] Plant Pigments

Occurrence, nomenclature and general methods of structure determination. Isolation and synthesis of Apigenin, Luteolin Quercetin, Myrcetin, Vitexin, Diadzein, Aureusin, Cyanidin, Hirsutidin, Biosynthesis of flavonoids: Acetate pathway and Shikimic acid pathway. Prophyrins:

Structure and synthesis of Haemoglobin and Chlorophyll.

[B] Pyrethroids and Rotenones

Synthesis and reactions of Pyrethroids and Rotenones. (For structure elucidation, emphasis is to be placed on the use of spectral parameters wherever possible).

Suggested Books:

1. Organic Chemistry : Vol. 1 and 2, I. L. Finar, ELBS

2. Organic Chemistry of Natural Products Vol. I and Vol. II, Gurdeep R. Chatwal, Himalaya Publishing House

3. Stereoselective Synthesis: A Practical Approach, M. Norgradi, VCH.

4. Rodd's Chemistry of Carbon Compounds, Ed. S. Coffey, Elsevier.

5.Introduction to Flavonoids, B.A. Bohm. Harwood Academic Publishers.

6. New Trends in Natural Product chemistry, Ataaur Rahman and M.L. Choudhary,

Harwood Academic Publishers.

7. Insecticides of Natural Origin, Sukh Dev, Harwood Academic Publishers.

MCH-403 Analytical Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-403: Analytical Chemistry Syllabus

Unit -I Statistical tests and Error Analysis:

Accuracy, precision, classification of errors, significant figures and computation, mean deviation and standard deviation, Least square methods, regression coefficient , F-test, t-test and Chi-test. 

 Sampling and Sample Treatment: Factors involved in effective sampling, good samples; Representative and homogeneous,

samples of mixtures.

Unit –II Spectrochemical and Thermal Methods :

Spectrophotometry: Quantities principles of absorption, instrumentation, single beam, double

beam, determination of pKa value of an indicator, detectors, applications.

Atomic spectroscopy: Principles of emissions, atomic emission spectroscopy and flame emission

spectroscopy, monochromator, detector, types of interferences,

Thermal methods of analysis: Principles and instrumentation of TG and DTA. Complementary

nature of TG and DTA. Differential scanning calorimeter (DSC). Applications of thermal

methods in analytical chemistry .

Unit –III Electroanalytical Methods:

Theory of electrogravimetric analysis, electrode reactions, over potential, Cyclic voltammetry,

Linear-scan voltammetry, Pulse voltammetric methods, stripping methods.

Coulometry : Coulometrc titrations and controlled- potential electrolysis.

Unit - IV Separation Techniques :

Classification of chromatographic separations. Theory of chromatography. Applications of

chromatographic methods: Adsorption and partition chromatography. Ion exchange

chromatography , LC, HPLC and GC, Column matrices, Detectors. Affinity and chiral

columns.

Principles of analytical separations, liquid –liqid extraction : Distribution coefficient,

distribution ratio, solvent extraction of metals, analytical separations, multiple batch extractions,

countercurrent distribution., multiple extractions.

Books Suggested

1. Gary D.Christian, Analytical Chemistry, John-Wiley

2. H.A.Willard, L.L.Merrit, and J.A.Dean, Instrumental Methods of Analysis, Van

Nostrand, New York, 1986.

3. D.A.Skoog & D.M.West Principles of Instrumental Analysis. Holt Rinahart Winston,

New York, 1988.

4. K A Robinsons Chemical Analysis, Harper Collins Publishers, NewYork.

5. A.J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications,

John Wiley & Sons: New York.

MCH-306 Advanced Medicinal Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-306: Advanced Medicinal Chemistry Syllabus

Unit –I : Antineoplastic agents

Introduction, cancer chemotherapy, role of alkylating agents and antimetabolite in treatment of cancer, carcinolytic antibiotics, and mitotic inhibitors, Synthesis of mechlorethamine,  cyclophosphamide, melphalan, uracil, mustards and 6-mercaptopurine, recent development in

cancer chemotherapy.

Unit –II : Psychoactive drugs-The chemotherapy of mind

Introduction, neurotransmitters, CNS depressants, general anesthetics, mode of action of hypnotics, sedatives, anti-anxiety drugs, benzodiazipines, buspirone, neurochemistry of mental

diseases, Anti psychotic drugs the neuroleptics, anti-depressants, butyro phenones, serendipity and drug development, stereo chemical aspects of psychotropic drugs. Synthesis of diazepam, oxazepam, chlorazepam, alprazolam, phenytoin, ethosuximide, trimethadione, barbiturates, thiopental sodium, gluthemide.

Unit –III : Tranquilizers:-

Phenothiazine derivatives - structure- activity relationship, metabolism and mode of action; other tranquilizers. Synthesis of chlorpromazine.

Sulpha Drugs:

Classification, structure-activity-relationship, Mode of action. Synthesis: Sulphadiazine, Sulphaisoxazole, Sulphadimethoxine.

Unit –IV: Diuretics (Drugs acting on renal system):

 Classification, structure-activity relationships and mode of action of organomercurials, phenoxy acetic acids, purines carbonic anhydrase inhibitors, benzothiadiazines , ulphamoyl benzoic acid derivatives, endocrine antagonists.

Books recommended

1. Robert F.dorge Wilson and Gisvod. Textbook of organic Medicinal and Pharmaceutical Chemistry.

2. Ed. M.E. Wolff, John wiley. Berger’s Medicinal Chemistry and drug discovery, Vol-I.

3. J.Faprhop and G.Penzillin. Organic synthesis-concept, method and starting material.

4. Eds.Korolkovas and Burkhattar J.H. John Wiley & sons. Essentials of medicinal Chemistry.

5. Goodman and Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill.

6. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry, Ed Robert F. Dorge.

MCH-401 Solid State Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-401: Solid State Chemistry Syllabus

Unit I : Solid State Reactions

General principles, experimental procedure, co-precipitation as a precursory to solid state reactions, kinetics of solid state reactions.

Unit II : Crystal Defects and Non-Stoichiometry

Perfect and imperfect crystals, intrinsic and extrinsic defects-point defects, line and plane defects, vacancies-Schottky detects and Frenkel defects. Thermodynamics of Schottky and Frenkel defect formation, colour centres, non-stoichiometry and defects.

 Unit III : Electronic Properties and Band Theory

Metal,s insulators and semiconductors, electronic structure of solidsband theory band structure  of metals, insulators and semiconductors, Intrinsic and extrinsic semiconductors, doping semiconductors, p-n junctions, super conductors. Optical properties-Application of optical and electron microscopy. Magnetic Properties-Classification of materials : Effect of temperature calculation of magnetic moment, mechanism of ferro and anti ferromagnetic ordering super exchange.

Unit IV : Organic Solids

Electrically conducting solids. organic charge transfer complex, organic metals, new superconductors. 

Books Suggested

1. Solid state chemistry and its applications, A.R. West. Peenum.

2. Principles of the Solid State, H.V. Keer, Wiley Eastern.

3. Solid State Chemistry, N.B. Hannay.

4. Solid State Chemistry, D.K. Chakrabarty, New Wiley Eastern.

MCH-107 PRACTICAL Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-307: PRACTICAL Syllabus

(A) Interpretations of Electronic, Infra-red, NMR, ESR, Mössbauer, Mass and XPS spectra

(B) Electronic Spectroscopy

i. Determination of kPa of an indicator (e.g. methyl red) in (a) aqueous and (b) micellar media.

ii. Determination of stoichiometry and stability constant of Ferricisothicoyanation complex ion in solution.

iii. Electronis spectral studies for transition metal complexes.

MCH-404 Bioorganic Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-404: Bioorganic Chemistry Syllabus 

Unit-I Introduction 

Basic Consideration, Proximity effects and molecular adoption.

Enzymes: Introduction, Chemical and Biological catalysis, remarkable properties of enzymes,

Nomenclature and classification, concept and identification of active site by use of inhibitors,

reversible & irreversible inhibition.

Unit-II Kinds of Reactions Catalyzed by Enzymes: 

B-cleavage and consideration, some isomerization

and rearrangement reactions. Enzyme catalyzed carboxylation and decarboxylation.

Mechanism of Enzyme action: Transition state theory, Orientation and steric effect, acid-base

catalysis, covalent catalysis.

Co-Enzyme Chemistry: 

Cofactors as derived from vitamins, coenzymes, prosthetic groups,

apoenzymes, Structure and biological functions of coenzyme A.

Unit-III Enzyme Models :

 Host guest chemistry, Chiral recognition and catalysis, molecular recognition,

molecular asymmetry and prochirality, Biomimetic chemistry, crown ethers, cryptates,

cyclodextrins, cyclodextrin based enzyme models, Calixarenes, ionophores, micelles synthetic

enzyme or synzymes.

Unit-IV Biotechnological Application of enzymes: 

Large scale production and purification of enzymes,

techniques and methods of immobilization of enzyme activity, application of immobilized

enzymes, effect of immobilization on Enzyme activity, application of immobilized enzymes.

Clinical uses of enzymes, enzyme therapy, enzymes and recombinant DNA technology.

Books Suggested

1. Bioorganic chemistry:A Chemical Approch to Enzyme action,Hermann Dugas and

C.Penny, Springer-Verag.

2. Understanding Enzymes, Trevor Palmer, Prentice Hall

3. Enzyme Chemistry: Impact and applications, Ed Collin J Suckling, Chapman and Hall

4. Enzyme mechanism a Ed. M.I.Page and A. Williams, Royal society of chemistry

5. Fundamentals of Enzymology, N.C. Price and L. Stevens, Oxford University Press.

6. Enzymattic Reaction Mechanism C. Walsh,W.H. Freeman.

7. Enzyme Structure and Mechanism A Fersht, W.H.Freeman.

8. Biochemistry : The Chemical reaction of leaving cells, D.E.Metzler, Academic Press.

9. Biochemistry(4th edn.) Stryer, L.W.; H.Freeman & Co.(1995)

10. Understanding Enzymes Palmer, T.; Prantice Hall (1995).

MCH-205: Organometallic Chemistry Syllabus M.Sc.(CHEMISTRY) 2nd-II Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Second-2nd- II Semester Curriculum/ Syllabus

MCH-205: Organometallic Chemistry Syllabus

Unit I : Main Group Organometallics

Synthesis and reactions of organolithium compounds; Synthesis and reactions of organomagnesium compounds; Organometallics of zinc and mercury: preparation, structure, bonding and reactions of aluminum organyls; Thallium(I) organyls (synthesis of TlCp); Organyls of sodium, synthesis of NaCp; Silicon and tin organyls of coordination number 4. 

 Unit II : Transition Metal–Carbon Bond

Transition Metal–Carbon σ-Bond: Brief review of metal alkyl compounds; transition metalcarbene and transition metal-carbyne compounds; transition metal vinylidene and transition metal allenylidene compounds. Cyclopropenyl cation (C3R3 +) as a ligand; C4R4 as a ligand (R = H, Me, Ph)

Unit III : Syntheses of Cyclopentadienyl and Arene Metal Analogues

Synthesis and reactions of cyclopentadienyl metal carbonyls, cyclopentadienyl metal hydrides, cyclopentadienyl metal halides, arene metal carbonyls, η6-arene-chromium tricarbonyl in organic synthesis.

Unit IV : Applications to Organic Synthesis and Homogeneous Catalysis

(a) In Organic Synthesis: Hydrozirconation of alkenes and alkynes; Carbonylation of Colman’s  reagent; η4-diene iron-tricarbonyls in organic synthesis

(b) In Catalysis: Asymmetric hydrogenation; synthesis of acetic acid and glycol (Monsanto acetic acid process); Arylation/vinylation of olefins (Heck reaction); Wacker process (olefin oxidation); Asymmetric epoxidation.

Text Books

1. C. Elschenbroich. Organometallics (3rd edn.), Wiley-VCH Publication (2006).

2. C. Elschenbroich & A. Salzer. Organometallics – A Concise Introduction (2nd edn.),VCH Publication (1992).

3. F. Mathey & A. Sevin. Molecular Chemistry of the Transition Elements, John Wiley (1996).

4. F. A. Cotton & G. Wilkinson. Advanced Inorganic Chemistry (5th edn.), John Wiley (1988).

5. R. C. Mehrotra & A. Singh. Organometallic Chemistry: A Unified Approach (2nd edn.), New

Age International (2000).

MCH-205-Organometallic-Chemistry-Syllabus-Msc-CHEMISTRY-2nd-II-Sem-Syllabus-for-DAVV-Indore-Affiliated-Institutions 

MCH-305 Organic Synthesis Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-305: Organic Synthesis Syllabus

Unit -I The disconnection approach (Retrosynthetic analysis):

Guidelines to choose disconnection, Synthons and synthetic equivalents, Functional group interconversion, the order of events and its guidelines, One-group C-X disconnections, Two-group C-X disconnections, Chemoselectivity, reversal of polarity, cyclization reactions and summary of strategy.Amine synthesis, Stereoselectivity, stereoselective reactions, stereospecific reactions

Unit - II : One group C-C disconnections

 Alcohols, carbonyl compounds, regioselectivity. Use of acetylenes Two-group C-C disconnections:Diels-Alder reactions (stereospecificity, stereoselectivity, endo-selectivity, regioselectivity), 1,3-Difunctionalised and ,- unsaturated carbonyl compounds, 1,5- Difunctionalised compounds, Michael addition and Robinson Annelation.

Unit – III : Oxidation Processes

Introduction, Different oxidative processes. Mn(VII) oxidants:Oxidation of alcohols,alkenes,alkynes,aldehydes,ketones,aromatic side chains and rings,amines Cr (VI) oxidants:Oxidation of alcohols /phenols(Jones reagent,Collins reagent,PCC,PDC), alkanes,alkenes,aromatic side chain and aromatic nucleus. Oxidation with peracids: oxidation of alkenes ,ketones.

Other oxidants: Oxidation with ruthenium tetraoxide, lead tetra acetate, thallium. (III) nitrate,potassium periodate,aluminium tri-isopropoxide and aluminium tri-t-butoxide, hydrogen

peroxide, t-Butyl hydroperoxide 

Unit- IV : Reduction Processes

Introduction, Different reductive processes. Catalytic hydrogenation: Heterogeneous hydrogenation, Homogeneous hydrogenation. Metal hydride reduction :Scope, Mechanism, stereochemical aspects of metal hydride reduction using lithium aluminium hydride,Sodium borohydride, Diboranes eduction by dissolving metals: Scope and basic mechanism, Clemensen reduction, Birch reduction Reduction by other reducing agents: Hydrazines, Diimide

Books suggested

1. S. Warren ,Designing Organic Synthesis, Wiley.

2. J. Fuhrhop and G. Penzillin, Organic synthesis – Concept, Methods and Starting Material, Verlage VCH.

3. W. Carruthers,Some Modren Methods of Organic Synthesis, Cambrige Univ. Press.

4. H.O. House, Modern Synthetic Reactions, W.A. Benjamin

5. V.K.Ahluwalia ,Organic Reaction Mechanisms, Narosa Publishing House

6. S.M.Mukherji and S.P.Singh,Reaction Mechanism in Organic Chemistry, Macmilan

7. J. March, Advanced Organic Synthesis: Reaction, Mechanisms and Structure, Wiley. 

MCH-206: Computational Methods in Chemistry Syllabus M.Sc.(CHEMISTRY) 2nd-II Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Second-2nd- II Semester Curriculum/ Syllabus

MCH-206: Computational Methods in Chemistry Syllabus

(This is a theory cum-laboratory course with more emphasis on laboratory work). 

Unit-I : Introduction to computers and Computing

Basic structure and functioning of computer with a PC as illustrative example. Operating systems with DOS as an example Introduction to UNIX and WINDOWS.

Unit-II : Computer Programming in FORTRAN/C/BASIC

(the language features are listed here with reference to FORTRAN. The instructor may choose another language such as BASIC or C the features may be replaced appropriately). Constants and variables. Operations and symbols Expressions. Arithmetic assignment statement. Input and output Format statement. Termination statements. Branching statements as IF or GO TO statement. LOGICAL variables. Double precession variables. Subscripted variables and DIMENSION. DO statement FUNCTION AND SUBROUTINE. COMMON and DATA statement

Unit-III : Programming in Chemistry

Developing of small computer codes (FORTRAN/C/BASIC) involving simple formulae in Chemistry, such as Van der Waals equation. Chemical kinetics (determination of Rate constant) Radioactive decay (Half Life and Average Life). Determination Normality, Molarity nd Molality of solutions. Evaluation Electronegativity of atom and Lattice Energy from experimental

determination of molecular weight and percentage of element organic compounds using data from experimental metal representation of molecules in terms of elementary structural features such as bond lengths, bodn angles, dihedral angles, etc.

Unit-IV : Use of Computer programmes

Operation of PC. Data Processing. Running of standard Programs and Packages such as MS WORD, MS EXCEL special emphasis on calculations and chart formations. X-Y plot. Use of Programs Chemcraft, Molden and PovRey.

Book Suggested :

• Fundamentals of Computer : V. Rajaraman (Prentice Hall)
• Computers in Chemistry : K.V. Raman (Tata Mc Graw Hill)
• Computer Programming in FORTRAN IV-V Rajaraman (Prentice Hall)

MCH-207: PRACTICAL Syllabus M.Sc.(CHEMISTRY) 2nd-II Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Second-2nd- II Semester Curriculum/ Syllabus

MCH-207: PRACTICAL Syllabus

Chromatography Separation of cations and anions by

Column Chromatography : Ion exchange.

Preparations

Preparation of selected inorganic compounds and their studies by I.R. electronic spectra, Mossbauer, E.S.R. and magnetic susceptibility measurements. Handling of air and moisture sensitive compounds.

Organic Synthesis

Aldol condensation Dibenzal acetone from benzaldehyde. Sandmeyer reactuion : p- Chlorotoluene from p-toluidine. Acetoacetic ester Condensation : Synthesis of ethyl-nbutylacetoacetate by A.E.E. condensation. Connizzaro reaction : 4-Chlorobenzaldehyde as substrate. Friedel Crafts reaction : b-Benzoyl propionic acid from succinic anhydride and benzene. Aromatic electrophilic sustitutions : Synthesis of p-nitroaniline and p-bromoaniline. The Products may be Characterized by Spectral Techniques.

Quantitative Analysis

Determination of the percentage or number of hydroxyl groups in an organic compound by acetylation method. Estimation of amines/phenols using bromate bromide solution/or acetylation method. Determination of lodine and Saponification values of an oil sample. Determination of DO, COD and BOD of water sample.

Conductometry

i. Determination of the velocity constant, order of the reaction and energy of activation for saponification of ethyl acetate by sodium hydroxide conductometrically.

ii. Determination of solubility and solubility product of sparingly soluble salts 9e.g. PbSO4, BaSO4) conductometrically.

iii. Determination of the strength of strong and weak acid in a given mixture conductometrically.

iv. to study of the effect of solvent on the conductance of AgNO3/acetic acid and to determine the degree of dissociation and equilibirum constant in different solvents and in their mixtures (DMSO, DMF, dioxane, acetone, water) and to test the validity of Debye- Huckel-Onsager theory.

v. Determination of the activity coefficient of zinc ions in the solution of 0.002 M zinc sulphate using Debye Huckel's limiting law.

Potentiometry/pH metry

1. Determination of strengths of halides in a mixture potentiometrically.

2. Determination of the valency of mercurous ions potentiometrically.

3. Determination of the strength of strong and weak acids in a given mixture using a

potentiometer/pH meter.

4. Determination of temperature dependence of EMF of a cell.

5. Determination of the formation constant of silver-ammonia complex and stoichiometry of

the complex potentiometrically.

6. Acid-base titration in a non-aqueous media using a pH meter.

7. Determination of activity and activity coefficient of electrolytes.

8. Determination of the dissociation constant of acetic acid in DMSO. DMF, acetone adn

dioxane by titrating it with KOH.

9. Determination of the dissociation constnat of monobasic/dibasic acid by albert-Sderjeant

method.

10. Determination of thermodynamic constants, DG, DS, and DH for the reaction by e.m.f.

method. Zn + H2SO4 -> ZnSO4 + 2 H

Polarimetry

1. Determination of rate constant for hydrolysis/inversion of sugar using a polarimeter.

2. Enzyme kinetics-inversion of sucrose.

Books Suggested

1. Vogel's Textbook of Quantitative Analysis, revised, J. Bassett, R.C. Denney, G.H. Jeffery and J. Mendham, ELBS.

2. Synthesis and Characterization of Inorganic Compounds, W.L. Jolly. Prentice Hall.

3. Experiments and Techniques in Organic Chemistry, D.P. Pasto, C. Johnson and M. Miller, Prentice Hall.

4. Macroscale and Microscale Organic Experiments, K.L. Williamson, D.C. Health.

5. Systematic Qualitative Organic Analysis, H. Middleton, Adward Arnold.

6. Handbook of Organic Analysis-qualitative and Quantitative. H. Clark, Adward Arnold.

7. Vogel's Textbook of Practical Organic Chemistry, A.R. Tatchell, John Wiley.

8. Practical Physical Chemistry, A.M. James and F.E. Prichard, Longman.

9. Findley's Practical Physical chemistry, B.P. Levitt, Longman.

10. Experimental Physical Chemistry, R.C. Das and B. Behera, Tata McGraw Hill. 

MCH-301 Molecular Spectroscopy Organic Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-301: Molecular Spectroscopy (Organic Chemistry) Syllabus

Unit -I : Ultraviolet and Visible spectroscopy

Fundamentals, effect of solvent and extending conjugation on electronic transitions, ultraviolet bands for carbonyl compounds, unsaturated carbonyl compounds, dienes, conjugated polyenes, Fieser Woodward rules for conjugated dienes and carbonyl compounds,ultraviolet spectra of aromatic compounds. Steric effect in biphenyls

Unit -II : Infrared Spectroscopy

 Characteristic vibrational frequencies of alkanes, alkenes, alkynes, aromatic compounds, alcohols, ethers, phenols and amines. Detailed study of vibrational frequencies of carbonyl compounds (ketones, aldehydes, esters, amides, acids, anhydrides,lactones, lactams and conjugated carbonyl compounds). Effect of hydrogen bonding and solvent effect on vibrational frequencies, overtones, combination bands and Fermi resonance

Unit –III : Nuclear Magnetic Resonance Spectroscopy

 General introduction and definition, chemical shift, spin-spin interaction, shielding mechanism, mechanism of measurement, chemical shift values and correlation for protons bonded to carbon (aliphatic, olefinic, aldehydic and aromatic) and other nuclei (alcohols, phenols, enols, carboxylic acids, amines, amides & mercapto), chemical exchange, effect of deuteration, Stereochemistry, hindered rotation, Karplus curvevariation of coupling constant with dihedral angle,NMR shift reagents,Solvent effects, Nuclear overhauser effect (NOE).

Carbon-13 NMR Spectroscopy: General considerations, chemical shift (aliphatic olefinic , alkyne, aromatic, heteroaromatic and carboynl carbon), coupling constants. Two dimensional NMR spectroscopy:COSY, HETCOR, NOESY, DEPT, HMBC and HMQC techniques 

Unit- IV : Mass Spectrometry 

Introduction, ion production EI, CI, FD, ESI and FAB, ion analysis, ion abundance, Mass spectral fragmentation of organic compounds, common functional groups, molecular ion peak, metastable ion peak, Mc Lafferty rearrangement , Nitrogen rule, High resolution mass spectrometry. Combined problems based on UV, IR, NMR and Mass spectral techniques

Books Suggested 

1. R.M. Silverstein, G.C. Bassler and T.C. Morrill, Spectrometric Identification of Organic Compounds, John Wiley

2. R.J. Abraham, J. Fisher and P. Loftus, Introduction to NMR spectroscopy, Wiley

3. J.R. Dyer, Application of Spectroscopy of Organic Compounds, Prentice Hall

4. D.H. Williams, I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata McGraw-Hill

5. Banwell, Fundamentals of Molecular Spectroscopy, Tata McGraw Hill

6. G. Aruldhas, Molecular Structure and Spectroscopy, Prentice Hall