MCH-306 Advanced Medicinal Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-306: Advanced Medicinal Chemistry Syllabus

Unit –I : Antineoplastic agents

Introduction, cancer chemotherapy, role of alkylating agents and antimetabolite in treatment of cancer, carcinolytic antibiotics, and mitotic inhibitors, Synthesis of mechlorethamine,  cyclophosphamide, melphalan, uracil, mustards and 6-mercaptopurine, recent development in

cancer chemotherapy.

Unit –II : Psychoactive drugs-The chemotherapy of mind

Introduction, neurotransmitters, CNS depressants, general anesthetics, mode of action of hypnotics, sedatives, anti-anxiety drugs, benzodiazipines, buspirone, neurochemistry of mental

diseases, Anti psychotic drugs the neuroleptics, anti-depressants, butyro phenones, serendipity and drug development, stereo chemical aspects of psychotropic drugs. Synthesis of diazepam, oxazepam, chlorazepam, alprazolam, phenytoin, ethosuximide, trimethadione, barbiturates, thiopental sodium, gluthemide.

Unit –III : Tranquilizers:-

Phenothiazine derivatives - structure- activity relationship, metabolism and mode of action; other tranquilizers. Synthesis of chlorpromazine.

Sulpha Drugs:

Classification, structure-activity-relationship, Mode of action. Synthesis: Sulphadiazine, Sulphaisoxazole, Sulphadimethoxine.

Unit –IV: Diuretics (Drugs acting on renal system):

 Classification, structure-activity relationships and mode of action of organomercurials, phenoxy acetic acids, purines carbonic anhydrase inhibitors, benzothiadiazines , ulphamoyl benzoic acid derivatives, endocrine antagonists.

Books recommended

1. Robert F.dorge Wilson and Gisvod. Textbook of organic Medicinal and Pharmaceutical Chemistry.

2. Ed. M.E. Wolff, John wiley. Berger’s Medicinal Chemistry and drug discovery, Vol-I.

3. J.Faprhop and G.Penzillin. Organic synthesis-concept, method and starting material.

4. Eds.Korolkovas and Burkhattar J.H. John Wiley & sons. Essentials of medicinal Chemistry.

5. Goodman and Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill.

6. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry, Ed Robert F. Dorge.

MCH-107 PRACTICAL Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-307: PRACTICAL Syllabus

(A) Interpretations of Electronic, Infra-red, NMR, ESR, Mössbauer, Mass and XPS spectra

(B) Electronic Spectroscopy

i. Determination of kPa of an indicator (e.g. methyl red) in (a) aqueous and (b) micellar media.

ii. Determination of stoichiometry and stability constant of Ferricisothicoyanation complex ion in solution.

iii. Electronis spectral studies for transition metal complexes.

MCH-305 Organic Synthesis Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-305: Organic Synthesis Syllabus

Unit -I The disconnection approach (Retrosynthetic analysis):

Guidelines to choose disconnection, Synthons and synthetic equivalents, Functional group interconversion, the order of events and its guidelines, One-group C-X disconnections, Two-group C-X disconnections, Chemoselectivity, reversal of polarity, cyclization reactions and summary of strategy.Amine synthesis, Stereoselectivity, stereoselective reactions, stereospecific reactions

Unit - II : One group C-C disconnections

 Alcohols, carbonyl compounds, regioselectivity. Use of acetylenes Two-group C-C disconnections:Diels-Alder reactions (stereospecificity, stereoselectivity, endo-selectivity, regioselectivity), 1,3-Difunctionalised and ,- unsaturated carbonyl compounds, 1,5- Difunctionalised compounds, Michael addition and Robinson Annelation.

Unit – III : Oxidation Processes

Introduction, Different oxidative processes. Mn(VII) oxidants:Oxidation of alcohols,alkenes,alkynes,aldehydes,ketones,aromatic side chains and rings,amines Cr (VI) oxidants:Oxidation of alcohols /phenols(Jones reagent,Collins reagent,PCC,PDC), alkanes,alkenes,aromatic side chain and aromatic nucleus. Oxidation with peracids: oxidation of alkenes ,ketones.

Other oxidants: Oxidation with ruthenium tetraoxide, lead tetra acetate, thallium. (III) nitrate,potassium periodate,aluminium tri-isopropoxide and aluminium tri-t-butoxide, hydrogen

peroxide, t-Butyl hydroperoxide 

Unit- IV : Reduction Processes

Introduction, Different reductive processes. Catalytic hydrogenation: Heterogeneous hydrogenation, Homogeneous hydrogenation. Metal hydride reduction :Scope, Mechanism, stereochemical aspects of metal hydride reduction using lithium aluminium hydride,Sodium borohydride, Diboranes eduction by dissolving metals: Scope and basic mechanism, Clemensen reduction, Birch reduction Reduction by other reducing agents: Hydrazines, Diimide

Books suggested

1. S. Warren ,Designing Organic Synthesis, Wiley.

2. J. Fuhrhop and G. Penzillin, Organic synthesis – Concept, Methods and Starting Material, Verlage VCH.

3. W. Carruthers,Some Modren Methods of Organic Synthesis, Cambrige Univ. Press.

4. H.O. House, Modern Synthetic Reactions, W.A. Benjamin

5. V.K.Ahluwalia ,Organic Reaction Mechanisms, Narosa Publishing House

6. S.M.Mukherji and S.P.Singh,Reaction Mechanism in Organic Chemistry, Macmilan

7. J. March, Advanced Organic Synthesis: Reaction, Mechanisms and Structure, Wiley. 

MCH-301 Molecular Spectroscopy Organic Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-301: Molecular Spectroscopy (Organic Chemistry) Syllabus

Unit -I : Ultraviolet and Visible spectroscopy

Fundamentals, effect of solvent and extending conjugation on electronic transitions, ultraviolet bands for carbonyl compounds, unsaturated carbonyl compounds, dienes, conjugated polyenes, Fieser Woodward rules for conjugated dienes and carbonyl compounds,ultraviolet spectra of aromatic compounds. Steric effect in biphenyls

Unit -II : Infrared Spectroscopy

 Characteristic vibrational frequencies of alkanes, alkenes, alkynes, aromatic compounds, alcohols, ethers, phenols and amines. Detailed study of vibrational frequencies of carbonyl compounds (ketones, aldehydes, esters, amides, acids, anhydrides,lactones, lactams and conjugated carbonyl compounds). Effect of hydrogen bonding and solvent effect on vibrational frequencies, overtones, combination bands and Fermi resonance

Unit –III : Nuclear Magnetic Resonance Spectroscopy

 General introduction and definition, chemical shift, spin-spin interaction, shielding mechanism, mechanism of measurement, chemical shift values and correlation for protons bonded to carbon (aliphatic, olefinic, aldehydic and aromatic) and other nuclei (alcohols, phenols, enols, carboxylic acids, amines, amides & mercapto), chemical exchange, effect of deuteration, Stereochemistry, hindered rotation, Karplus curvevariation of coupling constant with dihedral angle,NMR shift reagents,Solvent effects, Nuclear overhauser effect (NOE).

Carbon-13 NMR Spectroscopy: General considerations, chemical shift (aliphatic olefinic , alkyne, aromatic, heteroaromatic and carboynl carbon), coupling constants. Two dimensional NMR spectroscopy:COSY, HETCOR, NOESY, DEPT, HMBC and HMQC techniques 

Unit- IV : Mass Spectrometry 

Introduction, ion production EI, CI, FD, ESI and FAB, ion analysis, ion abundance, Mass spectral fragmentation of organic compounds, common functional groups, molecular ion peak, metastable ion peak, Mc Lafferty rearrangement , Nitrogen rule, High resolution mass spectrometry. Combined problems based on UV, IR, NMR and Mass spectral techniques

Books Suggested 

1. R.M. Silverstein, G.C. Bassler and T.C. Morrill, Spectrometric Identification of Organic Compounds, John Wiley

2. R.J. Abraham, J. Fisher and P. Loftus, Introduction to NMR spectroscopy, Wiley

3. J.R. Dyer, Application of Spectroscopy of Organic Compounds, Prentice Hall

4. D.H. Williams, I. Fleming, Spectroscopic Methods in Organic Chemistry, Tata McGraw-Hill

5. Banwell, Fundamentals of Molecular Spectroscopy, Tata McGraw Hill

6. G. Aruldhas, Molecular Structure and Spectroscopy, Prentice Hall

MCH-302 Photochemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-302: Photochemistry Syllabus

UNIT-I : Photochemical Reactions

Interaction of electromagnetic radiation with matter, types of excitations, fate of excited molecule, quantum yield, transfer of excitation energy, actinometry.

UNIT-II : Determination of Reaction Mechanism

Classification, rate constants and life times of reactive energy state determination of rate constants of reactions. Effect of light intensity on the rate of photochemical reactions, Types of 

photochemical reactions-photo dissociation, gas-phase photolysis.

UNIT-III : Photochemistry of Alkene

Intramolecular reactions of the olefinic bond-geometrical isomerism, cyclisation reactions, rearrangement of 1,4- and 1,5-dienes. 

Photochemistry of Aromatic Compounds

 Isomerisations, Additions and Substitutions.

UNIT-IV : Photochemistry of Carbonyl Compounds

Intramolecular reactions of carbonyl compounds-saturated, cyclic and acyclic,,γ- unsaturated and α,- unsaturated compounds, cyclohexadienones. Intermolecular cycloaddition reactionsdimerisations and oxetane formation.

 

Miscellaneous Photochemical Reactions

Photo-Fries reactions of anilides, Photo-Fries rearrangement. Barton reaction. Singlet molecular oxygen reaction. Photochemical formation of smog. Photodegration of polymers. Photochemistry of vision

Books Suggested

1. K.K. Rothagi-Mukheriji, Fundamentals of photochemistry, Wiley-Eastern.

2. A Gilbert and J. Baggott, Essentials of Molecular Photochemistry, Blackwell Scientific Publication.

3. N.J. Turro, Molecular Photochemistry, Benjamin.

4. A. Cox and T. Camp, Introductory Photochemistry, McGraw Hill.

5. R.P. Kundall and A. Gilbert, Photochemistry, Thomson Nelson.

6. J. Coxon and B.Holtom, Organic Photochemistry, Cambridge University Press.

7. C H Dupuoy and O L Chapman Molecular Reactions and Photochemistry, Prentice Hall

8. J Kagan, Organic Photochemistry, Academic Press

MCH-304 Bioinorganic Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-304: Bioinorganic Chemistry Syllabus

Unit I : Electron Transfer in Biology

Structure and function of metal of proteins in electron transport processes cytochrome's and ionsulphure proteins, synthetic models. Biological nitrogen fixation, and its mechanism, nitrogenase, Chemical nitrogen fixation.

Unit II : Metalloporphyrins

Structure and optical spectra; heme proteins: magnetic susceptibility, epr and electronic spectra; hemoglobin and myoglobin: molecular structures, thermodynamics and kinetics of oxygenation, electronic and spatial structures, synthetic oxygen carriers, model systems; iron enzymes, peroxidase, catalase and cytochrome P-450

Unit III: Metalloenzymes

Copper enzymes, superoxide dismutase, cytochrome oxidase and ceruloplasmin; Coenzymes; Molybdenum enzyme: xanthine oxidase; Zinc enzymes: carbonic anhydrase, carboxy peptidase

and interchangeability of zinc and cobalt in enzymes; Vitamin B12 and B12 coenzymes; Iron storage, transport, biomineralization and siderophores, ferritin and transferrins..

Unit IV: Metal Ions in Biological Systems

Bulk and trace metals with special reference to Na, K, Mg, Ca, Fe, Cu, Zn, Co, and K+/Na+ pump.

Text Books

1. 1. S. J. Lippard & J. M. Berg. Principles of Bioorganic Chemistry, Panima Publ. Corpn. (2005).

2. 2. E.-I. Ochiai. Bioinorganic Chemistry – An Introduction, Allyn and Bacon Inc. (1977).

3. 3. M. N. Hughes. The Inorganic Chemistry of Biological Processes, Wiley (1981).

4. 4. R.P. Hanzlik. Inorganic Aspects of Biological and Organic Chemistry, Academic Press (1976)

Reference Books

1. H. Kraatz & N. Metzler-Nolte (Eds.). Concepts and Models in Bioinorganic Chemistry, Wiley (2006).

2. I. Bertini, H. B. Gray, S. J. Dippard & J. S. Valentine, Bioinorganic Chemistry, Viva Books Pvt. Ltd. (2004).

3. A.W. Addison, W.R. Cullen, D. Dolphin & B.R. James (eds.). Biological Aspects of Inorganic Chemistry, John Wiley (1977).

MCH-303 Diffraction Techniques and ESCA Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-303: Diffraction Techniques and ESCA Syllabus

Unit-I : X-ray Diffraction

Bragg condition, Miller indices, Laue Method, Bragg method, Debye Scherrer method of X-ray structural analysis of crystals, index reflections, identification of unit cells from systematic absences in diffraction pattern, Structure of simple lattices and X-ray intensities, structure factor

and its relation to intensity and electron density, phase problem. Description of the procedure for an X-ray structure analysis, absolute configuration of molecules.

Unit-II : Electron Diffraction

Scattering intensity vs. scattering angle, Wierl equation, measurement technique, elucidation of structure of simple gas phase molecules. Low energy electron diffraction and structure of surfaces.

Unit-III : Neutron Diffraction 

Scattering of neutrons by solids measurement techniques, Elucidation of structure of magnetically ordered unit cells.

Unit IV : Photoelectron Spectroscopy

Basic principles; photo-electric effect, ionization process, Koopman's theorem. Photoelectron spectra of simple molecules, ESCA, chemical information from ESCA. Auger electron spectroscopy-basic idea.