MCH-306 Advanced Medicinal Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-306: Advanced Medicinal Chemistry Syllabus

Unit –I : Antineoplastic agents

Introduction, cancer chemotherapy, role of alkylating agents and antimetabolite in treatment of cancer, carcinolytic antibiotics, and mitotic inhibitors, Synthesis of mechlorethamine,  cyclophosphamide, melphalan, uracil, mustards and 6-mercaptopurine, recent development in

cancer chemotherapy.

Unit –II : Psychoactive drugs-The chemotherapy of mind

Introduction, neurotransmitters, CNS depressants, general anesthetics, mode of action of hypnotics, sedatives, anti-anxiety drugs, benzodiazipines, buspirone, neurochemistry of mental

diseases, Anti psychotic drugs the neuroleptics, anti-depressants, butyro phenones, serendipity and drug development, stereo chemical aspects of psychotropic drugs. Synthesis of diazepam, oxazepam, chlorazepam, alprazolam, phenytoin, ethosuximide, trimethadione, barbiturates, thiopental sodium, gluthemide.

Unit –III : Tranquilizers:-

Phenothiazine derivatives - structure- activity relationship, metabolism and mode of action; other tranquilizers. Synthesis of chlorpromazine.

Sulpha Drugs:

Classification, structure-activity-relationship, Mode of action. Synthesis: Sulphadiazine, Sulphaisoxazole, Sulphadimethoxine.

Unit –IV: Diuretics (Drugs acting on renal system):

 Classification, structure-activity relationships and mode of action of organomercurials, phenoxy acetic acids, purines carbonic anhydrase inhibitors, benzothiadiazines , ulphamoyl benzoic acid derivatives, endocrine antagonists.

Books recommended

1. Robert F.dorge Wilson and Gisvod. Textbook of organic Medicinal and Pharmaceutical Chemistry.

2. Ed. M.E. Wolff, John wiley. Berger’s Medicinal Chemistry and drug discovery, Vol-I.

3. J.Faprhop and G.Penzillin. Organic synthesis-concept, method and starting material.

4. Eds.Korolkovas and Burkhattar J.H. John Wiley & sons. Essentials of medicinal Chemistry.

5. Goodman and Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill.

6. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry, Ed Robert F. Dorge.