MCH-403 Analytical Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-403: Analytical Chemistry Syllabus

Unit -I Statistical tests and Error Analysis:

Accuracy, precision, classification of errors, significant figures and computation, mean deviation and standard deviation, Least square methods, regression coefficient , F-test, t-test and Chi-test. 

 Sampling and Sample Treatment: Factors involved in effective sampling, good samples; Representative and homogeneous,

samples of mixtures.

Unit –II Spectrochemical and Thermal Methods :

Spectrophotometry: Quantities principles of absorption, instrumentation, single beam, double

beam, determination of pKa value of an indicator, detectors, applications.

Atomic spectroscopy: Principles of emissions, atomic emission spectroscopy and flame emission

spectroscopy, monochromator, detector, types of interferences,

Thermal methods of analysis: Principles and instrumentation of TG and DTA. Complementary

nature of TG and DTA. Differential scanning calorimeter (DSC). Applications of thermal

methods in analytical chemistry .

Unit –III Electroanalytical Methods:

Theory of electrogravimetric analysis, electrode reactions, over potential, Cyclic voltammetry,

Linear-scan voltammetry, Pulse voltammetric methods, stripping methods.

Coulometry : Coulometrc titrations and controlled- potential electrolysis.

Unit - IV Separation Techniques :

Classification of chromatographic separations. Theory of chromatography. Applications of

chromatographic methods: Adsorption and partition chromatography. Ion exchange

chromatography , LC, HPLC and GC, Column matrices, Detectors. Affinity and chiral

columns.

Principles of analytical separations, liquid –liqid extraction : Distribution coefficient,

distribution ratio, solvent extraction of metals, analytical separations, multiple batch extractions,

countercurrent distribution., multiple extractions.

Books Suggested

1. Gary D.Christian, Analytical Chemistry, John-Wiley

2. H.A.Willard, L.L.Merrit, and J.A.Dean, Instrumental Methods of Analysis, Van

Nostrand, New York, 1986.

3. D.A.Skoog & D.M.West Principles of Instrumental Analysis. Holt Rinahart Winston,

New York, 1988.

4. K A Robinsons Chemical Analysis, Harper Collins Publishers, NewYork.

5. A.J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications,

John Wiley & Sons: New York.

MCH-306 Advanced Medicinal Chemistry Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-306: Advanced Medicinal Chemistry Syllabus

Unit –I : Antineoplastic agents

Introduction, cancer chemotherapy, role of alkylating agents and antimetabolite in treatment of cancer, carcinolytic antibiotics, and mitotic inhibitors, Synthesis of mechlorethamine,  cyclophosphamide, melphalan, uracil, mustards and 6-mercaptopurine, recent development in

cancer chemotherapy.

Unit –II : Psychoactive drugs-The chemotherapy of mind

Introduction, neurotransmitters, CNS depressants, general anesthetics, mode of action of hypnotics, sedatives, anti-anxiety drugs, benzodiazipines, buspirone, neurochemistry of mental

diseases, Anti psychotic drugs the neuroleptics, anti-depressants, butyro phenones, serendipity and drug development, stereo chemical aspects of psychotropic drugs. Synthesis of diazepam, oxazepam, chlorazepam, alprazolam, phenytoin, ethosuximide, trimethadione, barbiturates, thiopental sodium, gluthemide.

Unit –III : Tranquilizers:-

Phenothiazine derivatives - structure- activity relationship, metabolism and mode of action; other tranquilizers. Synthesis of chlorpromazine.

Sulpha Drugs:

Classification, structure-activity-relationship, Mode of action. Synthesis: Sulphadiazine, Sulphaisoxazole, Sulphadimethoxine.

Unit –IV: Diuretics (Drugs acting on renal system):

 Classification, structure-activity relationships and mode of action of organomercurials, phenoxy acetic acids, purines carbonic anhydrase inhibitors, benzothiadiazines , ulphamoyl benzoic acid derivatives, endocrine antagonists.

Books recommended

1. Robert F.dorge Wilson and Gisvod. Textbook of organic Medicinal and Pharmaceutical Chemistry.

2. Ed. M.E. Wolff, John wiley. Berger’s Medicinal Chemistry and drug discovery, Vol-I.

3. J.Faprhop and G.Penzillin. Organic synthesis-concept, method and starting material.

4. Eds.Korolkovas and Burkhattar J.H. John Wiley & sons. Essentials of medicinal Chemistry.

5. Goodman and Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill.

6. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry, Ed Robert F. Dorge.

MCH-401 Solid State Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-401: Solid State Chemistry Syllabus

Unit I : Solid State Reactions

General principles, experimental procedure, co-precipitation as a precursory to solid state reactions, kinetics of solid state reactions.

Unit II : Crystal Defects and Non-Stoichiometry

Perfect and imperfect crystals, intrinsic and extrinsic defects-point defects, line and plane defects, vacancies-Schottky detects and Frenkel defects. Thermodynamics of Schottky and Frenkel defect formation, colour centres, non-stoichiometry and defects.

 Unit III : Electronic Properties and Band Theory

Metal,s insulators and semiconductors, electronic structure of solidsband theory band structure  of metals, insulators and semiconductors, Intrinsic and extrinsic semiconductors, doping semiconductors, p-n junctions, super conductors. Optical properties-Application of optical and electron microscopy. Magnetic Properties-Classification of materials : Effect of temperature calculation of magnetic moment, mechanism of ferro and anti ferromagnetic ordering super exchange.

Unit IV : Organic Solids

Electrically conducting solids. organic charge transfer complex, organic metals, new superconductors. 

Books Suggested

1. Solid state chemistry and its applications, A.R. West. Peenum.

2. Principles of the Solid State, H.V. Keer, Wiley Eastern.

3. Solid State Chemistry, N.B. Hannay.

4. Solid State Chemistry, D.K. Chakrabarty, New Wiley Eastern.

MCH-107 PRACTICAL Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-307: PRACTICAL Syllabus

(A) Interpretations of Electronic, Infra-red, NMR, ESR, Mössbauer, Mass and XPS spectra

(B) Electronic Spectroscopy

i. Determination of kPa of an indicator (e.g. methyl red) in (a) aqueous and (b) micellar media.

ii. Determination of stoichiometry and stability constant of Ferricisothicoyanation complex ion in solution.

iii. Electronis spectral studies for transition metal complexes.

MCH-404 Bioorganic Chemistry Syllabus M.Sc.(CHEMISTRY) 4th-IV Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Fourth-4th-IV Semester Curriculum/ Syllabus

MCH-404: Bioorganic Chemistry Syllabus 

Unit-I Introduction 

Basic Consideration, Proximity effects and molecular adoption.

Enzymes: Introduction, Chemical and Biological catalysis, remarkable properties of enzymes,

Nomenclature and classification, concept and identification of active site by use of inhibitors,

reversible & irreversible inhibition.

Unit-II Kinds of Reactions Catalyzed by Enzymes: 

B-cleavage and consideration, some isomerization

and rearrangement reactions. Enzyme catalyzed carboxylation and decarboxylation.

Mechanism of Enzyme action: Transition state theory, Orientation and steric effect, acid-base

catalysis, covalent catalysis.

Co-Enzyme Chemistry: 

Cofactors as derived from vitamins, coenzymes, prosthetic groups,

apoenzymes, Structure and biological functions of coenzyme A.

Unit-III Enzyme Models :

 Host guest chemistry, Chiral recognition and catalysis, molecular recognition,

molecular asymmetry and prochirality, Biomimetic chemistry, crown ethers, cryptates,

cyclodextrins, cyclodextrin based enzyme models, Calixarenes, ionophores, micelles synthetic

enzyme or synzymes.

Unit-IV Biotechnological Application of enzymes: 

Large scale production and purification of enzymes,

techniques and methods of immobilization of enzyme activity, application of immobilized

enzymes, effect of immobilization on Enzyme activity, application of immobilized enzymes.

Clinical uses of enzymes, enzyme therapy, enzymes and recombinant DNA technology.

Books Suggested

1. Bioorganic chemistry:A Chemical Approch to Enzyme action,Hermann Dugas and

C.Penny, Springer-Verag.

2. Understanding Enzymes, Trevor Palmer, Prentice Hall

3. Enzyme Chemistry: Impact and applications, Ed Collin J Suckling, Chapman and Hall

4. Enzyme mechanism a Ed. M.I.Page and A. Williams, Royal society of chemistry

5. Fundamentals of Enzymology, N.C. Price and L. Stevens, Oxford University Press.

6. Enzymattic Reaction Mechanism C. Walsh,W.H. Freeman.

7. Enzyme Structure and Mechanism A Fersht, W.H.Freeman.

8. Biochemistry : The Chemical reaction of leaving cells, D.E.Metzler, Academic Press.

9. Biochemistry(4th edn.) Stryer, L.W.; H.Freeman & Co.(1995)

10. Understanding Enzymes Palmer, T.; Prantice Hall (1995).

MCH-205: Organometallic Chemistry Syllabus M.Sc.(CHEMISTRY) 2nd-II Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY) Second-2nd- II Semester Curriculum/ Syllabus

MCH-205: Organometallic Chemistry Syllabus

Unit I : Main Group Organometallics

Synthesis and reactions of organolithium compounds; Synthesis and reactions of organomagnesium compounds; Organometallics of zinc and mercury: preparation, structure, bonding and reactions of aluminum organyls; Thallium(I) organyls (synthesis of TlCp); Organyls of sodium, synthesis of NaCp; Silicon and tin organyls of coordination number 4. 

 Unit II : Transition Metal–Carbon Bond

Transition Metal–Carbon σ-Bond: Brief review of metal alkyl compounds; transition metalcarbene and transition metal-carbyne compounds; transition metal vinylidene and transition metal allenylidene compounds. Cyclopropenyl cation (C3R3 +) as a ligand; C4R4 as a ligand (R = H, Me, Ph)

Unit III : Syntheses of Cyclopentadienyl and Arene Metal Analogues

Synthesis and reactions of cyclopentadienyl metal carbonyls, cyclopentadienyl metal hydrides, cyclopentadienyl metal halides, arene metal carbonyls, η6-arene-chromium tricarbonyl in organic synthesis.

Unit IV : Applications to Organic Synthesis and Homogeneous Catalysis

(a) In Organic Synthesis: Hydrozirconation of alkenes and alkynes; Carbonylation of Colman’s  reagent; η4-diene iron-tricarbonyls in organic synthesis

(b) In Catalysis: Asymmetric hydrogenation; synthesis of acetic acid and glycol (Monsanto acetic acid process); Arylation/vinylation of olefins (Heck reaction); Wacker process (olefin oxidation); Asymmetric epoxidation.

Text Books

1. C. Elschenbroich. Organometallics (3rd edn.), Wiley-VCH Publication (2006).

2. C. Elschenbroich & A. Salzer. Organometallics – A Concise Introduction (2nd edn.),VCH Publication (1992).

3. F. Mathey & A. Sevin. Molecular Chemistry of the Transition Elements, John Wiley (1996).

4. F. A. Cotton & G. Wilkinson. Advanced Inorganic Chemistry (5th edn.), John Wiley (1988).

5. R. C. Mehrotra & A. Singh. Organometallic Chemistry: A Unified Approach (2nd edn.), New

Age International (2000).

MCH-205-Organometallic-Chemistry-Syllabus-Msc-CHEMISTRY-2nd-II-Sem-Syllabus-for-DAVV-Indore-Affiliated-Institutions 

MCH-305 Organic Synthesis Syllabus M.Sc.(CHEMISTRY) 3rd-III Sem Syllabus for DAVV Indore Affiliated Institutions

DEVI AHILYA VISHWAVIDYALAYA, DAVV INDORE Syllabus

M.Sc. (CHEMISTRY)Third-3rd-III Semester Curriculum/ Syllabus

MCH-305: Organic Synthesis Syllabus

Unit -I The disconnection approach (Retrosynthetic analysis):

Guidelines to choose disconnection, Synthons and synthetic equivalents, Functional group interconversion, the order of events and its guidelines, One-group C-X disconnections, Two-group C-X disconnections, Chemoselectivity, reversal of polarity, cyclization reactions and summary of strategy.Amine synthesis, Stereoselectivity, stereoselective reactions, stereospecific reactions

Unit - II : One group C-C disconnections

 Alcohols, carbonyl compounds, regioselectivity. Use of acetylenes Two-group C-C disconnections:Diels-Alder reactions (stereospecificity, stereoselectivity, endo-selectivity, regioselectivity), 1,3-Difunctionalised and ,- unsaturated carbonyl compounds, 1,5- Difunctionalised compounds, Michael addition and Robinson Annelation.

Unit – III : Oxidation Processes

Introduction, Different oxidative processes. Mn(VII) oxidants:Oxidation of alcohols,alkenes,alkynes,aldehydes,ketones,aromatic side chains and rings,amines Cr (VI) oxidants:Oxidation of alcohols /phenols(Jones reagent,Collins reagent,PCC,PDC), alkanes,alkenes,aromatic side chain and aromatic nucleus. Oxidation with peracids: oxidation of alkenes ,ketones.

Other oxidants: Oxidation with ruthenium tetraoxide, lead tetra acetate, thallium. (III) nitrate,potassium periodate,aluminium tri-isopropoxide and aluminium tri-t-butoxide, hydrogen

peroxide, t-Butyl hydroperoxide 

Unit- IV : Reduction Processes

Introduction, Different reductive processes. Catalytic hydrogenation: Heterogeneous hydrogenation, Homogeneous hydrogenation. Metal hydride reduction :Scope, Mechanism, stereochemical aspects of metal hydride reduction using lithium aluminium hydride,Sodium borohydride, Diboranes eduction by dissolving metals: Scope and basic mechanism, Clemensen reduction, Birch reduction Reduction by other reducing agents: Hydrazines, Diimide

Books suggested

1. S. Warren ,Designing Organic Synthesis, Wiley.

2. J. Fuhrhop and G. Penzillin, Organic synthesis – Concept, Methods and Starting Material, Verlage VCH.

3. W. Carruthers,Some Modren Methods of Organic Synthesis, Cambrige Univ. Press.

4. H.O. House, Modern Synthetic Reactions, W.A. Benjamin

5. V.K.Ahluwalia ,Organic Reaction Mechanisms, Narosa Publishing House

6. S.M.Mukherji and S.P.Singh,Reaction Mechanism in Organic Chemistry, Macmilan

7. J. March, Advanced Organic Synthesis: Reaction, Mechanisms and Structure, Wiley.